研究業績

2024年

  1. Palladium-Catalyzed Reductive Heck Hydroarylation of Unactivated Alkenes Using Hydrosilane at Room Temperature
    Shirai, T; Migitera, Y.; Nakajima, R.; Kumamoto, T. J. Org. Chem., 2024, 89, 2787-2793. LINK

  2. Targeted Therapy for Prostate Cancer by Prostate-Specific Membrane Antigen-Targeted Small-Molecule Drug Conjugates
    Nakajima, R. Chem. Pharm. Bull., 2024, 72, 136-142. LINK

  3. Hydrolytic dynamic kinetic resolution of racemic 3-phenyl-2-oxetanone to chiral tropic acid
    Kawasaki, M.; Shirai, T.; Yatsuzuka, K.; Shirai, R. RSC Adv., 2024, 14, 6121-6126. LINK

2023年

  1. Actinorhodin Biosynthesis Terminates with an Unprecedented Biaryl Coupling Reaction
    Hashimoto, M; Watari, S.; Taguchi, T.; Ishikawa, K.; Kumamoto, T.; Okamoto, S.; Ichinose, K. Angew. Chem. Int. Ed., 2023, 62, e202214400. LINK

  2. Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells
    Noguchi, S.; Kajimoto, T.; Kumamoto, T.; Shingai, M.; Narasaki, S.; Urabe, T.; Imamura, S.; Harada, K.; Hide, I.; Tanaka, S.; Yanase, Y.; Nakamura, S.-I.; Tsutsumi, Y. M.; Sakai, N. Front. Pharmacol. , 2023, 14, 1284586. LINK

2022年

  1. Asymmetric Total Synthesis of Brasiliquinones B and C via Oxidative Cyclization of a Hydroquinone-Silyl Enol Ether Hybrid
    Miyake, H.; Nakajima, R.; Kumamoto, T. J. Org. Chem., 2022, 87, 12491. LINK

2021年

  1. Total Synthesis of 6-Deoxydihydrokalafungin, a Key Biosynthetic Precursor of Actinorhodin, and Its Epimer
    Kumamoto, T.; Kainuma, M.; Takahashi,S.; Matsuo, Y.; Katakawa, K.; Taguchi, T.; Ichinose, K. Molecules, 2021, 23, 6397. LINK

  2. Direct N1-Selective Alkylation of Hydantoins Using Potassium Bases
    Shintani, Y.; Kato, K.; Kawami, M.; Takano, M.; Kumamoto, T. Chem. Pharm. Bull., 2021, 69, 407-411. LINK

  3. Total Synthesis of (±)-4-Deoxyblennolide C via Spirochromanone
    Kumamoto, T.; Hasegawa, S.; Adachi, K.; Katakawa, K. Heterocycles, 2021, 103, 1064-1077. LINK

2020年

  1. Possible utility of peptide-transporter-targeting [19F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging
    Arakawa, H.; Yamada, H.; Arai, K.; Kawanishi, T.; Nitta, N.; Shibata, S.; Matsumoto, E.; Yano, K.; Kato, Y.; Kumamoto, T.; Aoki, I.; Ogihara, T. Int. J. Pharmaceut., 2020, 586, 119575 LINK

  2. Practical and Scalable Synthesis of a Glucokinase Activator via One-pot Difluorination and Julia Olefination
    Tsuchiya, H.; Iwamoto, M.; Miyamoto, H.; Sakumoto, C.; Tamamizu, T.; Inoshita, Y.; Koyama, Y.; Sato, Y.; Kumamoto, T. Org. Process Res. Dev., 2020, 24, 1294$20131303. LINK

  3. Unveiling Two Consecutive Hydroxylations: Mechanism of Aromatic Hydroxylations Catalyzed by Flavin‐Dependent Monooxygenases for Biosynthesis of Actinorhodin and Related Antibiotics
    Hashimoto, M.: Taguchi, T.; Ishikawa, K.; Mori, R.; Hotta, A.; Watari, S.; Katakawa, K.; Kumamoto, T.; Okamoto, S.; Ichinose, K. ChemBioChem，2020, 21, 623-627. LINK

  4. Chemistry of Anti-Hiv Active Trimeric Pyranonaphthoquinone Conocurvone: Synthetic Studies towards Monomeric Teretifolione B and Related Compounds (review)
    Kumamoto, T.; Katakawa, K. Heterocycles，2020, 100, 177-193. LINK

2019年

  1. Recent Progress in Aryne Cycloaddition Reactions
    Kumamoto, T.; Katakawa, K.
    in Cycloaddition Reactions: Advances in Research and Applications, Margetic, D. Ed., Nova Science, 2019. LINK

2018年

  1. 2-Aminoadipic acid-C(O)-glutamate based prostate-specific membrane antigen ligands for potential use as theranostics
    Nakajima, R.; Novakova, Z.; Tueckmantel, W.; Motlova, L.; Barinka, C.; Kozikowski, A. P. ACS Med. Chem. Lett., 2018, 9, 1099-1104. LINK

  2. 抗 HIV 活性三量体ベンゾクロメン Conocurvone とその単量体の化学：単量体 Teretifolione B とその関連化合物の合成研究
    片川 和明, 熊本 卓哉，有機合成化学協会誌, 2018, 76, 722-729. LINK

  3. Design, synthesis, and evaluation of polyamine-memantine hybrids as NMDA channel blockers
    Kumamoto, T.; Nakajima, M.; Uga, R.; Ihayazaka, N.; Kashihara, H.; Katakawa, K.; Ishikawa, T.; Saiki, R.; Nishimura, K.; Igarashi, K. Bioorg. Med. Chem.，2018 26, 603-608. LINK

  4. Preparation of Optically Active 2,2-Disubstituted 5-Hydroxychromenes by the Enzymatic Resolution of Racemic Esters
    Kainuma, M.; Yamada, A.; Katakawa, A.; Kumamoto, T. Heterocycles, 2018, 97, 604-611. LINK

2017年

  1. Total synthesis of (+)-blennolide C and (+)-gonytolide C via spirochromanone
    Adachi, K.; Hasegawa, S.; Katakawa, K.; Kumamoto, T.Tetrahedron Lett.，2017 58, 4479-4482. LINK

  2. Asymmetric total syntheses of teretifolione B and methylteretifolione B via Diels-Alder reaction of optically active pyranobenzyne and substituted furans
    Katakawa, A.; Kainuma, M.; Suzuki, K.; Tanaka, S.; Kumamoto, T. Tetrahedron, 2017, 73, 5063-5071. LINK